Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H.
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):570-582.
Walsh M, Merkel PA, Peh CA, Szpirt WM, Puéchal X, Fujimoto S, Hawley CM, Khalidi N, Floßmann O, Wald R, Girard LP, Levin A, Gregorini G, Harper L, Clark WF, Pagnoux C, Specks U, Smyth L, Tesar V, Ito-Ihara T, de Zoysa JR, Szczeklik W, Flores-Suárez LF, Carette S, Guillevin L, Pusey CD, Casian AL, Brezina B, Mazzetti A, McAlear CA, Broadhurst E, Reidlinger D, Mehta S, Ives N, Jayne DRW; PEXIVAS Investigators.
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis.
N Engl J Med. 2020 Feb 13;382(7):622-631.
Tanaka A, Kono H, Leung PSC, Gershwin ME.
Recurrence of disease following organ transplantation in autoimmune liver disease and systemic lupus erythematosus.
Cell Immunol. 2020 Jan;347:104021.
Yokoyama N, Kawasaki A, Matsushita T, Furukawa H, Kondo Y, Hirano F, Sada KE, Matsumoto I, Kusaoi M, Amano H, Nagaoka S, Setoguchi K, Nagai T, Shimada K, Sugii S, Hashimoto A, Matsui T, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Migita K, Kono H, Hasegawa M, Kobayashi S, Yamada H, Nagasaka K, Sugihara T, Yamagata K, Ozaki S, Tamura N, Takasaki Y, Hashimoto H, Makino H, Arimura Y, Harigai M, Sato S, Sumida T, Tohma S, Takehara K, Tsuchiya N.
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not
with ANCA-associated vasculitis in a Japanese population.
Sci Rep. 2019 Nov 8;9(1):16366.
Furukawa H, Oka S, Kawasaki A, Hidaka M, Shimada K, Kondo Y, Ihata A, Matsushita T, Matsumoto T, Hashimoto A, Matsumoto I, Komiya A, Kobayashi K, Osada A, Katayama M, Okamoto A, Setoguchi K, Kono H, Hamaguchi Y, Matsui T, Fukui N, Tamura H, Takehara K, Nagaoka S, Sugii S, Sumida T, Tsuchiya N, Tohma S.
Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy.
Mod Rheumatol. 2019 Jul 18:1-7.
Takenaka K, Minami T, Yoshihashi Y, Hirata S, Kimura Y, Kono H.
Decrease in MPO-ANCA after administration of benralizumab in eosinophilic granulomatosis with
polyangiitis.
Allergol Int. 2019 Oct;68(4):539-540.
Kitazawa T, Seo K, Yoshino Y, Asako K, Kikuchi H, Kono H, Ota Y.
Efficacies of atovaquone, pentamidine, and trimethoprim/sulfamethoxazole for the prevention of
Pneumocystis jirovecii pneumonia in patients with connective tissue diseases.
J Infect Chemother. 2019 May;25(5):351-354.
Liu Y, Ikawa T, Tada Y, Tanaka T, Ohnishi T, Watanabe S, Tsukui D, Asako K, Kono H.
Two Severe Cases of Adult-onset Still’s Disease with Persistent Pruritic Eruptions.
Acta Derm Venereol. doi: 10.2340/00015555-2887. 2018
Tsukui D, Kono H.
Ultraviolet Purpura in IgA Vasculitis.
Mayo Clin Proc. 93(1):122, 2018
Mimura T, Kondo Y, Ohta A, Iwamoto M, Ota A, Okamoto N, Kawaguchi Y, Kono H,Takasaki Y, Takei S, Nishimoto N, Fujimoto M, Asanuma YF, Mimori A, Okiyama N, Kaneko S, Takahashi H, Yokosawa M, Sumida T. Evidence-based clinical practice guideline for adult Still’s disease.
Mod Rheumatol. 2018 Sep;28(5):736-757.
Yamanaka M, Fujigaki Y, Kono H, Nagura M, Arai S, Tamura Y, Ota T, Shibata S, Kondo F, Yamaguchi Y, Uchida S.
A patient presenting with isolated hematuria and renal dysfunction as rare manifestation of cryoglobulinemic glomerulonephritis in the course of autoimmune diseases including Sjögren’s syndrome.
CEN Case Rep.2018 Nov;7(2):211-216.
Kawasaki A, Yamashita K, Hirano F, Sada KE, Tsukui D, Kondo Y, Kimura Y, Asako K, Kobayashi S, Yamada H, Furukawa H, Nagasaka K, Sugihara T, Yamagata K, Sumida T, Tohma S, Kono H, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N.
Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population.
J Hum Genet. 63(1):55-62, 2018
Shono Y, Kamata M, Takeoka S, Ikawa T, Tateishi M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Asako K, Kono H, Tada Y.
Cutaneous sarcoidosis in a patient with rheumatoid arthritis receiving tocilizumab.
J Dermatol. 2018 Aug;45(8):e217-e218.
Kimura Y, Asako K, Kikuchi H, Kono H
Refractory optic perineuritis due to granulomatosis with polyangiitis successfully treated with methotrexate and mycophenolate mofetil combination therapy.
Eur J Rheumatol. 4(1):70-72, 2017
Abe G, Kikuchi H, Arinuma Y, Hirohata S
Brain MRI in patients with acute confusional state of diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematous.
Modern rheumatol. 27(2):278-283, 2017
Morimoto C, Fujigaki Y, Tamura Y, Ota T, Shibata S, Asako K, Kikuchi H, Kono H, Kondo F, Yamaguchi Y, Uchida S.
Emergence of Smoldering ANCA-associated Glomerulonephritis During the Clinical Course of Mixed Connective Tissue Disease and Sjögren’s Syndrome.
Intern Med. doi:10.2169/internalmedicine.9844-17. 2017
Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
Association of HLA-G 3′ Untranslated Region Polymorphisms with Systemic Lupus Erythematosus in a Japanese Population: A Case-Control Association Study.
PLoS One. 11(6):e0158065. 2016
Onda A, Kono H, Jiao Q, Akimoto T, Miyamoto T, Sawada Y, Suzuki K, Kusakari Y, Minamisawa S, Fukubayashi T.
New mouse model of skeletal muscle atrophy using spiral wire immobilization.
Muscle Nerve. 54(4):788-91, 2016
Furukawa H, Oka S, Kawasaki A, Shimada K, Sugii S, Matsushita T, Hashimoto A, Komiya A, Fukui N, Kobayashi K, Osada A, Ihata A, Kondo Y, Nagai T, Setoguchi K, Okamoto A, Chiba N, Suematsu E, Kono H, Katayama M, Hirohata S, Sumida T, Migita K, Hasegawa M, Fujimoto M, Sato S, Nagaoka S, Takehara K, Tohma S, Tsuchiya N. Human Leukocyte Antigen and Systemic Sclerosis in Japanese: The Sign of the Four Independent Protective Alleles, DRB1*13:02, DRB1*14:06, DQB1*03:01, and DPB1*02:01.
PLoS One. 11(4):e0154255. 2016
Kimura Y, Asako K, Kikuchi H, Kono H.
Characteristics of patients with intestinal Behçet’s disease requiring treatment with immunosuppressants or anti-TNFα antibody.
Mod Rheumatol. 26(1):132-137, 2016
Hibi T, Hirohata S, Kikuchi H, Tateishi U, Sato N, Ozaki K, Kondo K, Ishigatsubo Y
Infliximab therapy for intestinal, neurological and vascular involvement in Behcet disease:Efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label, single-arm phase 3 study.
Medicine. 95(24):e3863, 2016
Kimura Y, Asako K, Kikuchi H, Hoshimoto K, Sasajima Y, Kono H
Relapsing Polychondritis Complicated by Vasculitis of the Omentum.
Internal Medicine. 55(10):1363-1366, 2016
Nakano R, Nakano A, Ishii Y, Ubagai T, Kikuchi-Ueda T, Kikuchi H, Tansho-Nagakawa S, Kamoshida G, Mu X, Ono Y.
Rapid detection of the Klebsiella pneumoniae carbapenemase (KPC) gene by loop-mediated isothermal amplification (LAMP).
J Infect Chemother. 21(3):202-6, 2015
Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y.
Retrospective analysis of long-term outcome of chronic progressive neurological manifestations in Behcet’s disease.
J Neurol Sci. 349(1-2):143-8, 2015
Kamoshida G, Kikuchi-Ueda T, Tansho-Nagakawa S, Nakano R, Nakano A, Kikuchi H, Ubagai T, Ono Y.
Acinetobacter baumannii escape from neutrophil extracellular traps
J Infect Chemother. 21(1):43-9, 2015
Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T.
Activation of an innate immune receptor, nod1, accelerates atherogenesis in apoe-/- mice.
J Immunol. 194(2):773-80, 2015
Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y.
Analysis of various factors on the relapse of acute neurological attacks in Behçet’s disease.
Mod Rheumatol. 24(6):961-5, 2014
Arinuma Y, Kikuchi H, Wada T, Nagai T, Tanaka S, Oba H, Hirohata S.
Brain MRI in patients with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus.
Lupus Sci Med. 1(1):e000050. 2014
Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N.
Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.
PLoS One. 9(10):e109764. 2014
Kono H, Kimura Y, Latz E.
Inflammasome activation in response to dead cells and their metabolites.
Curr Opin Immunol. 30:91-8, 2014
Kataoka H, Kono H, Patel Z, Kimura Y, Rock KL.
Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses.
PLoS One. 9(8):e104741. 2014
Hajime Kono, Akiko Onda, Tamiko Yanagida
Molecular determinants of sterile inflammation
Cuurent Opin Immunol. 26:147-56, 2014
Furukawa H, Kawasaki A, Oka S, Ito I, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Amano H, Nagai T, Hirohata S, Setoguchi K, Kono H, Okamoto A, Chiba N, Suematsu E, Katayama M, Migita K, Suda A, Ohno S, Hashimoto H, Takasaki Y, Sumida T, Nagaoka S, Tsuchiya N, Tohma S.
Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03.
PLoS One. 3;9(2):e87792, 2014
De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T,Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E.
High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3
Nat Immunol. 15(2):152-60, 2014
Kikuchi H, Takayama M, Hirohata S.
Quantitative Analysis of Brainstem Atrophy on Magnetic Resonance Imaging in Chronic Progressive Neuro-Behçet’s Disease.
J Neurological Sci. November 28, 2013; doi:10.1016/j.jns. 2013.11.020.
Yokoseki A, Saji E, Arakawa M, Kosaka T, Hokari M, Toyoshima Y, Okamoto K, Takeda S, Sanpei K, Kikuchi H, Hirohata S, Akazawa K, Kakita A, Takahashi H, Nishizawa M, Kawachi I.
Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody.
Brain. November 22, 2013; doi:10.1093/brain/awt314.
Yanagida T, Orihashi K, Kono H.
In vivo evaluation of neutrophil recruitment in response to sterile particulates.
Methods Mol Biol. 1040:211-21, 2013
Nakano R, Okamoto R, Nakano A, Nagano N, Abe M, Tansho-Nagakawa S, Ubagai T, Kikuchi-Ueda T, Koshio O, Kikuchi H, Ono Y.
Rapid assay for detecting gyrA and parC mutations associated with fluoroquinolone resistance in Enterobacteriaceae.
J Microbiol Methods. 94(3):213-216, 2013
Furukawa H, Oka S, Shimada K; Rheumatoid Arthritis-Interstitial Lung Disease Study Consortium, Tsuchiya N, Tohma S.
HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multidrug hypersensitivity marker?
Ann Rheum Dis. 72: 153-5, 2013.
Hirohata S, Kikuchi H.
Changes in biomarkers focused on differences in disease course or treatment in patients with neuro-Behçet’s disease.
Intern Med. 51:3359-65, 2012
Kikuchi H, Asako K, Tansho S, Ueda T, Koshio O, Ubagai T, Asahara M, Kawakami S, Ono Y.
Recurrent Helicobacter cinaedi cellulitis and bacteremia in a patient with systemic lupus erythematosus.
Intern Med. 51: 3185-8, 2012
Kono H, Orlowski GM, Zubin P, Rock KL.
The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C.
J Immunol 189: 3734-40, 2012
Tansho-Nagakawa S, Ubagai T, Kikuchi-Ueda T, Koshio O, Koshibu Y, Kikuchi H, Ono Y.
Analysis of membrane antigens on neutrophils from patients with sepsis.
J Infect Chemother. 18: 646-51, 2012
Kikuchi H, Yamamoto T, Asako K, Takayama M, Shirasaki R, Ono Y.
Etanercept for the treatment of intractable hemophagocytic syndrome with systemic lupus erythematosus.
Mod Rheumatol. 22: 308-11, 2012
Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y.
Clinical characteristics of neuro-Behcet’s disease in Japan: a multicenter retrospective analysis.
Mod Rheumatol. Sep 21, 2011. DOI: 10.1007/s10165-011-0533-5
Asako K, Takayama M, Kono H, Kikuchi H.
Churg-Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature.
Mod Rheumatol. 21 : 519-23, 2011.
Hirohata S, Nagai T, Asako K, Tomita T, Yoshikawa H.
Induction of type B synoviocyte-like cells from plasmacytoid dendritic cells of the bone marrow in rheumatoid arthritis and osteoarthritis.
Clin Immunol. 140: 276-83, 2011.
Arinuma Y, Kikuchi H, Aramaki K, Kyogoku M, Hirohata S.
Histopathological analysis of cerebral hemorrhage in systemic lupus erythematosus complicated with antiphospholipid syndrome.
Mod Rheumatol. 21: 509-13, 2011.
Nagatani K, Komagata Y, Asako K, Takayama M, Yamamoto K.
Antigen-specific regulatory T cells are detected in Peyer’s patches after the interaction between T cells and dendritic cells loaded with orally administered antigen.
Immunobiology. 216: 416-22, 2011.
Rock KL, Lai JJ, Kono H.
Innate and adaptive immune reponses to cell death.
Immunol Rev. 243: 191-205, 2011.
Duewell P#, Kono H# Rayner K, Sirois CM, Vladimer G, Bauernfeind FG, Rock KL, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Moore KJ, Wright SD, Hornung V#, Latz E# (# equal contribution).
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Nature 464: 1357-1361, 2010
Kono H, Chen CJ, Ontiveros F, Rock KL.
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
J Clin Invest. 120: 1939-1949, 2010
Kono H, Karmarkar D, Iwakura Y, Rock KL.
Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death.
J Immunol. 184: 4470-4478, 2010
Rock KL, Latz E, Ontiveros F, Kono H.
The sterile inflammatory response.
Annu Rev Immunol. 28: 321-342, 2010
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